Tumor suppressor genes represent a broad class of genes that normally function in the negative regulation of cell proliferation. Loss‐of‐function mutations in these genes lead to unrestrained cell proliferation and tumor formation. A fundamental understanding of how tumor suppressor genes regulate cell proliferation and differentiation should reveal important aspects of signalling pathways and cell cycle control. A recent report describing the Drosophila tumor suppressor gene warts has implications in the study of the human myotonic dystrophy gene(1). These genes encode members (...) of a cyclic AMP‐dependent protein kinase subfamily that includes other plant and animal orthologues. (shrink)

Until recently, Albert Einstein's complaints in his later years about the intelligibility of Quantum Mechanics often led philosophers and physicists to dismiss him as, essentially, an old fool in his dotage. Happily, this kind of thing is now coming to an end as philosophers and mathematicians of the caliber of Karl Popper and Roger Penrose conspicuously point out the continuing conceptual difficulties of quantum theory [cf. Penrose's searching discussion in The Emperor's New Mind, chapter 6, "Quantum magic and quantum mystery," (...) Oxford 1990]. The Paradox of Schrödinger's Cat is sometimes now even presented, not as a wonderful exciting implication of the theory, but for what it originally was: a reductio ad absurdum argument against the "new" quantum mechanics of Heisenberg and Bohr. Schrödinger shared the misgivings of Einstein and others. (shrink)

Policy feedback, or the process in which policies create constituencies vested in their maintenance, is a durable feature of the American welfare state. Scholars have shown that policy visibility conditions how feedback effects unfold: for public-private policies—arrangements in which the state delegates service provision to private actors, often described as “hidden” or “submerged”—policy feedback typically galvanizes not citizens but market actors that benefit indirectly from these subsidies. This article extends theories of public-private policy feedback from market actors to charitable organizations (...) through a case study of the charitable contributions deduction. The deduction’s incremental expansion is found to have mobilized charities as powerful stakeholders in the policy’s endurance. Charities’ efforts to protect the deduction, together with the efforts of lawmakers, have couched the policy in a politics of neoliberalism and disguised its effects, insulating it from reform even as elites have netted a greater share of its benefits over time. (shrink)

For several decades the work of Joel Feinberg has been the most influential in legal, political and social philosophy in the English-speaking world. This 1994 volume honours that body of work by presenting fifteen essays, many of them by leading legal and political philosophers, that explore the problems that have engaged Feinberg over the years. Amongst the topics covered are issues of autonomy, responsibility and liability. It will be a collection of interest to anyone working in moral, legal or political (...) philosophy. (shrink)

Globalization leads to cross-border business transactions between societies with very different norms and regulations regarding bribery. Bribery in international business transactions can be seen as a function of not only the demand for such bribes in different countries, but the supply, or willingness to provide bribes by multinational firms and their representatives. This study addresses the propensity of firms from 30 different countries to engage in international bribery. The study incorporates both domestic (economic development, culture, and domestic corruption in the (...) supplying country) and international factors (those countries’ patterns of trade and involvement in international accords) in explaining the willingness to bribe abroad. The propensity to provide bribes was the lowest when corruption was not tolerated in the multinational firms’ home countries, when the firms’ countries were signatories of the Organization for Economic Cooperation and Development (OECD) anti-bribery convention, and when those countries traded heavily with wealthier nations. Further, these findings are maintained when controlling for levels of economic development and cultural values in the supplying country. In terms of culture, firms from high power distance countries showed a somewhat greater propensity for providing bribes in transactions with less-developed nations. (shrink)

We hypothesize that black women experience accelerated biological aging in response to repeated or prolonged adaptation to subjective and objective stressors. Drawing on stress physiology and ethnographic, social science, and public health literature, we lay out the rationale for this hypothesis. We also perform a first population-based test of its plausibility, focusing on telomere length, a biomeasure of aging that may be shortened by stressors. Analyzing data from the Study of Women’s Health Across the Nation (SWAN), we estimate that at (...) ages 49–55, black women are 7.5 years biologically “older” than white women. Indicators of perceived stress and poverty account for 27% of this difference. Data limitations preclude assessing objective stressors and also result in imprecise estimates, limiting our ability to draw firm inferences. Further investigation of black-white differences in telomere length using large-population-based samples of broad age range and with detailed measures of environmental stressors is merited. (shrink)

ABSTRACT:Despite widespread attention to corruption and organizational change in the literature, to our knowledge, no research has attempted to understand the linkages between these two powerful organizational phenomena. Accordingly, we draw on major theories in ethics, sociology, and management to develop a theoretical framework for understanding how organizational change can sometimes generate corruption. We extend anomie theory and ethical climate theory to articulate the deinstitutionalization of the normative control system and argue that, through this deinstitutionalization, organizations have the potential to (...) become incubators for corruption. We qualify this process by proposing conditions more ripe for anomie and under which this deinstitutionalization is more likely to occur, propounding moderating relationships that influence organizational reconfiguration. Examples of turbulence in the contemporary business environment that can trigger change highlight our discussion. We conclude with managerial implications, offering means by which the deleterious effects of corruption may be arrested or controlled. (shrink)

Click on the DOI link to access the article.

In this open peer commentary, we categorize the possible “neuroscience in national security” definitions of misuse of science and identify which, if any, are uniquely presented by advances in neuroscience. To define misuse, we first define what we would consider appropriate use: the application of reasonably safe and effective technology, based on valid and reliable scientific research, to serve a legitimate end. This definition presents distinct opportunities for assessing misuse: misuse is the application of invalid or unreliable science, or is (...) the use of reliable scientific methods to serve illegitimate ends. Ultimately, we conclude that while national security is often a politicized issue, assessing the state of scientific progress should not be. (shrink)

Jerome Popp's monograph is a part of the SUNY series in philosophy and biology, and accordingly is narrowly focused upon discussion of an evolutionary model of value theory. As Popp explains at the outset, Daniel Dennett—among others—has proposed that any naturalized moral theory must provide a naturalized account for its own existence. Popp's thesis for this work is that, in conjunction with his longoverlooked insight into the significance of Darwin's thought to the area of epistemology generally, Dewey solved this philosophic (...) problem long ago. This emphasis upon reconciling Dewey's work with Dennett's thought is reiterated in Popp's conclusion that "It is remarkable how Dewey's use of evolution in his arguments .. (shrink)

Clinical ethics consultants face a wide range of ethical dilemmas that require broad knowledge and skills. Although there is considerable overlap with the approach to adult consultation, ethics consultants must be aware of differences when they work with infant, pediatric, and adolescent cases. This article addresses unique considerations in the pediatric setting, reviews foundational theories on parental authority, suggests practical approaches to pediatric consultation, and outlines current available resources for clinical ethics consultants who wish to deepen their skills in this (...) area. (shrink)

Handwashing is important in preventing infectious diseases like COVID-19. The current public health emergency has required rapid implementation of increased handwashing in the general public; however, rapidly changing health behavior, especially on this scale, is difficult. This study considers attitudes and affective responses to handwashing as possible factors predicting COVID-19 related changes to handwashing behavior, future intentions, and readiness to change during the early stages of the pandemic in the United States. Income was explored as a potential moderator to these (...) relationships. To explore these issues, data from 344 community participants were analyzed. Results indicate that stronger affective responses toward handwashing relate to increases in handwashing since the outbreak of COVID-19, and both attitudes and affect uniquely predict handwashing intentions. Income significantly moderated the relationship between affect and readiness to change. Those with low income were more influenced by both affective responses and attitudes. These results suggest messages targeting both cognitions and affective responses are needed to increase the handwashing behavior during a global pandemic and these variables are critical in increasing readiness to change in low-income individuals. (shrink)

In Tyranny of the Gene: Personalized Medicine and Its Threat to Public Health (Knopf, 2023), James Tabery traces the ascendance of personalized or precision medicine in America, arguing that America's emphasis on genetics offers more hype than transformational power. In his examination of the power struggles, social relationships, and technological advances that centered the gene in American health policy, Tabery demonstrates how an intensive focus on genetics draws attention away from both the fundamental causes of health disparities and more‐effective changes (...) that could be made to developmental, physical, and social environments. American policy‐makers, health care institutions, funders, and bioethicists should not let the technological shine and attractive politics of personalized medicine continue to replace the hard but necessary work of addressing sociopolitical causes of disease and illness. (shrink)

Although research integrity practices in institutional settings is not a new area of study, because of its foundational importance in university settings it remains a topic worthy of study. In addition, rarely are all members of the university community included as participants in studies focused upon research integrity and ethics. Thus, to add to the existent literature, the authors investigated research integrity practices in a medium-sized Midwestern polytechnic university setting, including 467 participants from across all divisions of the university community. (...) This mixed data survey study was comprised of six sections; presented is information for two sections—sample demographics and research integrity. The demographics appear reflective of those of the larger survey, as well as the university setting of study. In the research integrity section there were two parts—one qualitative and one quantitative. Implications with regard to research integrity and ethics in the institutional setting of study are presented. (shrink)

Although research integrity practices in institutional settings is not a new area of study, because of its foundational importance in university settings it remains a topic worthy of study. In addition, rarely are all members of the university community included as participants in studies focused upon research integrity and ethics. Thus, to add to the existent literature, the authors investigated research integrity practices in a medium-sized Midwestern polytechnic university setting, including 467 participants from across all divisions of the university community. (...) This mixed data survey study was comprised of six sections; presented is information for two sections—sample demographics and research integrity. The demographics appear reflective of those of the larger survey, as well as the university setting of study. In the research integrity section there were two parts—one qualitative and one quantitative. Implications with regard to research integrity and ethics in the institutional setting of study are presented. (shrink)

Confirmed COVID-19 cases in the United States increased exponentially, quickly leading to a pandemic in 2020, which created a serious public-health emergency. During the period in which the COVID-1...

This article integrates research on gendered organizations and the work-family interface to investigate an innovative workplace initiative, the Results-Only Work Environment, implemented in the corporate headquarters of Best Buy, Inc. While flexible work policies common in other organizations “accommodate” individuals, this initiative attempts a broader and deeper critique of the organizational culture. We address two research questions: How does this initiative attempt to change the masculinized ideal worker norm? And what do women’s and men’s responses reveal about the persistent ways (...) that gender structures work and family life? Data demonstrate the ideal worker norm is pervasive and powerful, even as employees begin critically examining expectations regarding work time that have historically privileged men. Employees’ responses to ROWE are also gendered. Women are more enthusiastic, while men are more cautious. Ambivalence about and resistance to change is expressed in different ways depending on gender and occupational status. (shrink)

Since its early American inception, the Ph.D. has been the hallmark of American higher education. Yet it has not been above controversy. Recent discussions of its purpose vis-a-vis teaching and professional endeavors have continued a long tradition of examining graduate education. This bibliography offers an entree to the Ph.D. phenomenon. Of interest to administrators, educators, and scholars, the volume covers the history, research, and evolution of the Ph.D. An introductory essay offers an historical overview of the degree and sets the (...) degree within the context of contemporary research. The entries, organized into four sections, cover the controversies, critical studies, and purpose of the Ph.D. degree for science and technology, social science, and the humanities disciplines. (shrink)

This study focuses on a set of dreams related to the September 11, 2001 terrorist attacks and their aftermath, using content analysis and cognitive psychology to explore the interweaving of external public catastrophe and internal psychological processes. The study tests several recent claims in contemporary dream research, including the central image theory of Hartmann [Hartmann, E., & Basile, R. . Dream imagery becomes more intense after 9/11/01. Dreaming, 13, 61–66; Hartmann, E., & Brezler, T. . A systematic change in dreams (...) after 9/11/01. Sleep, 31, 213–218], the media exposure factor postulated by Propper [Propper, R. E., Stickgold, R., Keeley, R., & Christman, S. D. . Is television traumatic? Dreams, stress, and media exposure in the aftermath of September 11, 2001. Psychological Science, 18, 334–340], the continuity hypothesis of Domhoff [Domhoff, W. G. . Finding meaning in dreams: A quantitative approach. New York: Plenum], the cognitive and metacognitive approach of Kahan [Kahan, T. L. . Consciousness in dreaming: A metacognitive approach. In K. Bulkeley , Dreams: A reader on the religious, cultural, and psychological dimensions of dreaming . New York: Palgrave], and the threat simulation theory of Revonsuo [Revonsuo, A. . The reinterpretation of dreams: An evolutionary hypothesis of the function of dreaming. Behavioral and Brain Sciences, 23, 877–901]. Our findings suggest the terrorist attacks had a tangible impact on the content of many people’s dreams, but did not fundamentally alter the cognitive processing features of their dreaming. The 9/11 attacks affected what they dreamed about, but not the way they dreamed. (shrink)

In this work, all the discourses addressed to lay people in the four main nik?yas of the P?li Canon, and most of those in the fifth, have been surveyed, categorised, and analysed. The different ways in which the Buddha customised his style of teaching and the Dhamma being taught according to the various demographic characteristics of his audience are explored, highlighted and discussed. Some of the findings are to be expected, whereas others are less so. There are several clear gender (...) and class differences in the type of discourse used, the topics of the teaching, and in whether the sutta is oriented to lead the listener to the more worldly goals of happiness in this life or a good rebirth, as opposed to being directed towards complete liberation from rebirth. There are differences too based on the age of the addressees, but less pronounced. This survey has also brought forth some distinct characteristics of the different nik?yas of the P?li Canon in terms of their suttas to the lay community. The A?guttara Nik?ya contains more suttas targeted directly to lay people, plus many others of the ‘indirect’ variety, more suttas addressed to women and to the middle-class, and a higher emphasis on the goals of happiness in this life and a good rebirth. Overall the suttas addressed to lay people show a very strong emphasis on good conduct by body, speech, and mind. But this paper hasn’t addressed whether there would be a different emphasis shown in an examination of the suttas addressed exclusively to the monastic community, and this is an area that warrants further exploration. A comprehensive catalogue of suttas in the P?li Canon that are addressed to householders is included in an appendix. (shrink)

We demonstrate that the key components of cognitive architectures (declarative and procedural memory) and their key capabilities (learning, memory retrieval, probability judgment, and utility estimation) can be implemented as algebraic operations on vectors and tensors in a high‐dimensional space using a distributional semantics model. High‐dimensional vector spaces underlie the success of modern machine learning techniques based on deep learning. However, while neural networks have an impressive ability to process data to find patterns, they do not typically model high‐level cognition, and (...) it is often unclear how they work. Symbolic cognitive architectures can capture the complexities of high‐level cognition and provide human‐readable, explainable models, but scale poorly to naturalistic, non‐symbolic, or big data. Vector‐symbolic architectures, where symbols are represented as vectors, bridge the gap between the two approaches. We posit that cognitive architectures, if implemented in a vector‐space model, represent a useful, explanatory model of the internal representations of otherwise opaque neural architectures. Our proposed model, Holographic Declarative Memory (HDM), is a vector‐space model based on distributional semantics. HDM accounts for primacy and recency effects in free recall, the fan effect in recognition, probability judgments, and human performance on an iterated decision task. HDM provides a flexible, scalable alternative to symbolic cognitive architectures at a level of description that bridges symbolic, quantum, and neural models of cognition. (shrink)

Homer has a unique understanding of the body. On his view the body is that by means of which we are subject to moods, and moods are what attune us to our situation. Being attuned to a situation, in turn, opens us to the various ways things and people can be engaging. We agree with Homer that this receptivity is evident throughout our entire existence. It characterizes everything from our basic bodily skills for coping with objects and people to our (...) tendency to be immersed in and guided by moods such as the erotic or the agonistic – whole ways for a situation to matter. (shrink)